Penicillin G Potassium

Penicillin G Potassium Injection, USP (equivalent to 1, 2, or 3 million units of penicillin G) is a 50 mL premixed, iso-osmotic, sterile, nonpyrogenic, frozen solution for intravenous administration. Dextrose, USP has been added to the above dosages to adjust osmolality (approximately 2 g, 1.2 g, and 350 mg as dextrose hydrous, respectively). Sodium Citrate, USP has been added as a buffer. The pH has been adjusted with hydrochloric acid and may have been adjusted with sodium hydroxide. The pH is 6.5 (5.5 to 8.0). The solution is contained in a single dose GALAXY container (PL 2040 Plastic) and is intended for intravenous use after thawing to room temperature. Penicillin G Potassium, USP is a natural penicillin. It is chemically designated 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-[(phenylacetyl)amino]-monopotassium salt, [2S-(2α, 5α, 6β)]. It is crystalline. It is freely soluble in water, in isotonic sodium chloride solution and in dextrose solutions. The structural formula is as shown below. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Penicillin G Potassium Injection, USP and other antibacterial drugs, Penicillin G Potassium Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Bimedia PenAqua Sol-G antibiotic contains the active ingredient Penicillin G Potassium in a powder form. Used for the treatment of erysipelas, caused by Erysipelothrix rhusiopathiae in turkeys. Pre-measured, ready-to-use foil pouches make it easy to prepare stock solution. May be use in automatic or gravity-flow watering systems. For oral use in turkeys only.

Directions (1.000 billion I.U. Pouch):
Dissolve contents of pouch in 4 pints (1893 mL) of water in a glass or plastic container
Shake well to dissolve
Allow the concentrated solution to stand until foam disappears
The concentrated solution should be used up or discarded within one hour of preparation

Automatic Watering Systems:
Pour the concentrated solution into a glass or plastic container, then add enough water to make 5.2 gallons (19.7 liters) of stock solution
This amount of solution will medicate 666 gallons (2521 liters) of drinking water
The automatic waterer should be adjusted to deliver 1 ounce (30 mL) of stock solution per gallon (3.8 liters) of drinking water
Prepare fresh stock solutions and medicated drinking water solutions every 12 hours
All solutions in contact with galvanized metal should be changed every 3 hours

Gravity Flow Watering Systems:
Pour the concentrated solutions into enough water to make 666 gallons (2521 liters) of drinking water
In gravity flow watering systems, prepare fresh solutions every 12 hours
All solutions in contact with galvanized metal should be changed every 3 hours
Drinking water prepared as directed above will contain 1,500,000 units of penicillin G potassium per gallon (3.8 liters)

Warnings
Treated turkeys must not be slaughtered for food during treatment and for one day after last treatment
Do not use in turkeys producing eggs for human consumption
Restricted Drug (California) - Use Only as Directed

Directions (0.500 billion I.U. Pouch):
Dissolve contents of pouch in 2 pints (946 mL) of water in a glass or plastic container.
Shake well to dissolve.
Allow the concentrated solution to stand until foam disappears
The concentrated solution should be used up or discarded within one hour of preparation

Automatic Watering Systems:
Pour the concentrated solution into a glass or plastic container, then add enough water to make 2.6 gallons (9.9 liters) of stock solution
This amount of solution will medicate 333 gallons (1260 liters) of drinking water
The automatic waterer should be adjusted to deliver 1 ounce (30 mL) of stock solution per gallon (3.8 liters) of drinking water
Prepare fresh stock solutions and medicated drinking water solutions every 12 hours
All solutions in contact with galvanized metal should be changed every 3 hours

Gravity Flow Watering Systems:
Pour the concentrated solutions into enough water to make 333 gallons (1260 liters) of drinking water
In gravity flow watering systems, prepare fresh solutions every 12 hours
All solutions in contact with galvanized metal should be changed every 3 hours
Drinking water prepared as directed above will contain 1,500,000 units of penicillin G potassium per gallon (3.8 liters)

Precautions:
For best results, the treatemnt should be started at the first sign of infection. If improvement is not noted after 3 to 4 days of treatment, consult a poultry pathologist or veterinarian. Use only as directed.

Storage:
Store at or below 25°C (77°F). Protect from excessive heat, 40°C (104°F), and moisture.

Label recommendations for storage and replacement of stock and medicated water solutions must be followed to assure the performance of this drug product.

Penicillin G Potassium Highlights:

• SKU: 13833
• Manufacturer: Mwi Veterinary Supply
• It works by killing bacteria that cause infections.
• A nasogastric tube may be placed for feeding.
• Penicillin G Potassium belongs to a class of drugs
• Assisted ventilation may be necessary if respiratory paralysis has developed.
• Penicillin G injection is used to treat and prevent certain infections caused by bacteria
• Polyvalent antitoxin greatly increases the chance of survival, although it is very expensive
• Good nursing and supportive care are essential Potassium may be used alone or with other medications
• Alternatively, in regions where the most common type of botulism is known, monovalent antitoxin is a great alternative.