Draxxin KP Injectable Solution

Draxxin KP (tulathromycin and ketoprofen Injection) injectable antibiotic for cattle contains two ingredients in one shot for fast recovery of BRD. Formulated with the same active ingredient as Draxxin (tularthromycin), with the addition of a non-steroidal anti-inflammatory (NSAID), ketoprofen. Use for the treatment of bovine respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. This combination of active ingredients helps cattle recover faster from BRD-related fever, helping them feel better, sooner.* After one dose, Draxxin KP rapidly reaches therapeutic levels and maintains antibacterial therapeutic level for 14 days.

Draxxin KP includes the well-known effectiveness of Draxxin (tulathromycin injection) Injectable Solution and adds ketoprofen, a fast-acting nonsteroidal anti-inflammatory drug (NSAID), in a single treatment approved for use in beef steers, beef heifers, beef calves two months of age and older, beef bulls, dairy bulls and dairy replacement heifers. “With BRD, there can be an underlying fever, which can progress quickly and lead to appetite loss,” said Shawn Blood, DVM, managing technical services veterinarian at Zoetis. “Using an NSAID together with an antibiotic can aid treatment response and reduce the fever that typically comes with BRD compared with using an antibiotic treatment alone. Draxxin KP provides the option and convenience to have two powerful, effective ingredients working together.”

One Shot, Two Effective Ingredients 
In one subcutaneous injection, Draxxin KP starts working fast — both products have a rapid onset1 — against fever and four major bacterial pathogens associated with BRD:

Control fever: Because Draxxin KP includes an NSAID, it controls the fever that typically comes with BRD. The fast-acting anti-inflammatory, ketoprofen, has been demonstrated to reduce temperatures in as little as one hour.

Treat four major BRD pathogens: Draxxin KP provides the same long-acting antibacterial activity that Draxxin has against four major bacterial pathogens (Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis) associated with BRD for up to 14 days.

Indications
Draxxin KP is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis, and control of pyrexia associated with BRD in beef steers, beef heifers, beef calves 2 months of age and older, beef bulls, dairy bulls, and replacement dairy heifers. Not for use in reproducing animals over one year of age, dairy calves, or veal calves.

Instructions
Administer a single dose at a rate of 1.1 ml per 100 lbs bodyweight subcutaneously in the neck. Do not inject more than 10 ml per injection site. Use this product within 56 days of the first puncture and puncture a maximum of 20 times. If more than 20 punctures are anticipated, the use of automatic injection equipment or a repeater syringe is recommended. When using a draw-off spike or needle with bore diameter larger than 16 gauge, immediately discard any product remaining in the vial after use.

DOSAGE AND ADMINISTRATION
Inject subcutaneously as a single dose in the neck at a dosage of 2.5 mg tulathromycin and 3 mg ketoprofen/kg (1.1 mL/100 lb) bodyweight (BW). Do not inject more than 10 mL per injection site. Use this product within 56 days of the first puncture and puncture a maximum of 20 times. If more than 20 punctures are anticipated, the use of automatic injection equipment or a repeater syringe is recommended. When using a draw-off spike or needle with bore diameter larger than 16 gauge, discard any product remaining in the vial immediately after use.

Available Sizes for Draxxin KP:

• 50 ML
• 100 ML
• 250 ML
• 500 ML

Animal Safety Warnings and Precautions
The effects of DRAXXIN KP on bovine reproductive performance, pregnancy, and lactation have not been determined. Not for use in reproducing animals over one year of age because reproductive safety testing has not been conducted. Administration of tulathromycin and ketoprofen injection may result in injection site swelling that appears the day after treatment and may persist for at least 32 days post-injection. This may result in trim loss of edible tissue at slaughter.

As a class, cyclo-oxygenase inhibitory NSAIDs (Ketoprofen) may be associated with gastrointestinal, hepatic and renal toxicity. Sensitivity to drug-associated adverse effects varies with the individual patient. Patients at greatest risk for renal toxicity are those that are dehydrated, on concomitant diuretic therapy, or those with renal, cardiovascular, and/or hepatic dysfunction. Use judiciously when renal impairment or gastric ulceration is suspected.

Since many NSAIDs possess the potential to induce gastrointestinal ulceration, concomitant use of DRAXXIN KP with other anti-inflammatory drugs, such as other NSAIDs and corticosteroids, should be avoided or closely monitored. Discontinue use if fecal blood is observed.

Draxxin KP Highlights:

• SKU: draxxin_kp_cp
• Manufacturer: Zoetis
• Meat withhold, 18 days
• One dose provides 14 days of therapy
• Same volume dosing as Draxxin Injectable antibiotic for cattle
• Not for human use. Keep out of reach of children
• Not for use in beef calves under 2 months of age, dairy calves or veal calves
• Store at or below 25 °C (77 °F), with excursions up to 40 °C (104 °F). Protect from freezing
• Provides significant BRD fever reduction from 1 hour up to 24 hours post treatment in comparison to Draxxin alone
• Draxxin KP animals showed numerically improved attitude and respiratory scores compared with saline-treated and Draxxin animals post-treatment
• A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in animals previously found to be hypersensitive to tulathromycin and ketoprofen
• Not for use in female dairy cattle 1 year of age or older, including dry dairy cows; use in these cattle may cause drug residues in milk and/or in the calves born to these cows or heifers
• Many NSAIDs possess the potential to induce gastrointestinal ulceration, concomitant use of Draxxin KP with other anti-inflammatory drugs, such as other NSAIDs and corticosteroids, should be avoided or closely monitored. Discontinue use if fecal blood is observed