Titanium 5 L5 HB [100 mL] (50 Doses)

Titanium 5 L5 HB contains desiccated Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine and a bacterin diluent (Lepto 5 HB). Titanium 5 L5 HB is a multiantigenic modified live vaccine to be used as an aid in the prevention of disease caused by infectious bovine rhinotracheitis virus (IBR), bovine virus diarrhea virus (BVD), bovine parainfluenza3 virus (PI3), and bovine respiratory syncytial virus (BRSV) and a bacterin to aid in the prevention of disease caused by Leptospira borgpetersenii serovar hardjo-bovis and Leptospira canicola, Leptospira grippotyphosa, Leptospira hardjo, Leptospira icterohaemorrhagiae, and Leptospira pomona.

The five viral antigens are combined in the proper ratio, stabilized and desiccated into one cake. The desiccated viral fractions are rehydrated for use with a specially processed liquid Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin, Lepto 5. The desiccated fraction contains no bovine serum, virtually eliminating extraneous virus contamination and possible allergic reactions. Controlled tests conducted in our laboratory demonstrated that animals receiving a 10x dose did not shed BRSV or PI3 viruses. Control animals, housed with vaccinates, remained seronegative throughout the testing period.

The fetal loss in the two groups was similar with 3.43% in the Titanium 5 L5 HB vaccinated groups and 4.65% in the control groups. Following calving, each calf’s health was monitored for 4 weeks. The health of the calves in the Titanium 5 L5 HB vaccinated dams was similar to the health of calves born to the control dams.

DIRECTIONS AND DOSAGE
Rehydrate the desiccated vial with accompanying diluent and shake well. Inject 2 mL subcutaneously using aseptic technique, followed by a second dose of monovalent bovine respiratory syncytial virus vaccine (Titanium BRSV) to be given 14 to 28 days after the first dose. Annual revaccination is recommended. Calves vaccinated before weaning should be revaccinated 30 days after weaning when the possible influence of maternal antibodies is decreased.

WARNING
Fetal health risks associated with vaccination of pregnant animals with modified live vaccines cannot be unequivocally determined by clinical trials conducted for licensure. Vaccination of pregnant animals with modified live vaccines should be discussed with a veterinarian.

SAFETY
Safety in pregnant heifers and cows was demonstrated in trials conducted at three separate sites. The heifers and cows were vaccinated prior to breeding with Titanium 5 L5 HB, followed by a post-breeding vaccination at the first, second or third trimester of pregnancy. The cows were observed from pregnancy vaccination through calving for fetal loss. Heifers and cows vaccinated with Titanium 5 L5 HB had abortions and calving rates similar to the control cows.

Titanium 5 L5 HB [100 mL] (50 Doses) Highlights:

• SKU: 13256
• Manufacturer: Elanco
• Annual revaccination is recommended
• Proven protection against BVDV type 1b and type 2
• Studies showed Titanium provides 110-day duration of immunity against IBR
• Now USDA-approved to help prevent Lepto hardjo-bovis
• The cows were observed from pregnancy vaccination through calving for fetal loss
• Calves vaccinated before weaning should be revaccinated 30 days after weaning when the possible influence of maternal antibodies is decreased