Inforce 3 [100 mL] (50 Doses)

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Inforce 3 [100 mL] (50 Doses)

This 50 dose vial of Inforce 3 is used for the vaccination of healthy cattle, including pregnant cows, for the prevention of respiratory disease caused by BRSV, and as an aid in preventing respiratory disease caused by IBR and PI3. For vaccination of healthy cattle 3 days of age or older, including pregnant cows, to prevent respiratory disease caused by bovine respiratory syncytial virus (BRSV), and as an aid in preventing respiratory disease caused by infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. A duration of immunity of at least 193 days has been demonstrated against IBR; duration of immunity against BRSV and PI3 has not been established.


In a safety study conducted with INFORCE 3, no significant adverse reactions related to vaccination were observed. Safety has been demonstrated in calves as young as 0 days of age, weaned calves, high-stressed stockers, and pregnant cows in all 3 trimesters.

Efficacy of the BRSV fraction of INFORCE 3 was demonstrated in two vaccination-challenge studies. Calves were administered either a single 2-mL dose in one nostril or 1-mL doses in each nostril. One hundred percent of calves as young as 3 days of age, vaccinated with a 2-mL dose administered in a single nostril and challenged 49 and 57 days later survived virulent challenge. In both studies, INFORCE 3 vaccinates experienced significantly lower mortality, significantly less lung damage and significantly less viral shedding for a significantly shorter duration than control cattle.

Efficacy of the PI3 fraction was also demonstrated in two vaccination-challenge studies, conducted as described above. In both studies, calves vaccinated with INFORCE 3 were protected against a virulent PI3 challenge, as evidenced by shortened durations of virus shedding, when compared with non-vaccinated control calves. Short- and long-term efficacy of the IBR fraction were demonstrated in two studies. In the first study, weaned, 7- to 9-month-old vaccinated calves demonstrated 95% less incidence and a 95.6% reduction in disease duration compared to controls when challenged 28 days after vaccination.

Researchers also saw favorable impacts on rectal temperatures and nasal shedding of virus. In the second study, calves as young as 3 days of age were vaccinated with a single 2-mL dose and challenged more than 6 months (193 days) later. Vaccinates were observed to have 75.6% less incidence of IBR and a 63.8% reduction in duration of disease compared to controls. Favorable impacts on temperature, nasal shedding, and antibody titers were also seen.

Directions For Use
General Directions: Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, shake well, and administer 2 mL intranasally (IN) using a cannula or a syringe with the needle removed.

Primary Vaccination: Place the 2-mL dose in one nostril, or half the dose (1 mL) in each nostril. The presence of maternal antibody is known to interfere with the development of active immunity in cattle, and additional boosters will be required in most young animals.

Inforce 3 [100 mL] (50 Doses) Highlights:

  • SKU: 14449
  • Manufacturer: Zoetis
  • Contains gentamicin as preservative.
  • Use entire contents when first opened.
  • Do not vaccinate within 21 days before slaughter.
  • Do not mix with other products, except as specified above.
  • Sterilized syringes should be used to administer this vaccine.
  • Store at 2°-8°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.
More Information
SKU 14449
Manufacturer Zoetis
Volume (ML) 100 ML
Hazardous No
Shipping Restriction Do Not Ship To Canada
Unit of Measure each
Virus Type Modified Live
Dose 50 DS
Product Label Click Here
SDS Click Here
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  • Refrigeration is required, and a cooler handling charge will be added to your order.